Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders
Abstract Emotional behavior, memory, and learning have been associated with alterations in the immune system in neuropsychiatric and neurodegenerative diseases.…
cannabinoid receptor 2 (CB2R)
New Insights and Potential Therapeutic Targeting of CB2 Cannabinoid Receptors in CNS Disorders
Abstract The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in the regulation of mental health. Consequently,…
Cannabinoids for the Treatment of Dermatologic Conditions
Abstract In recent years, cannabinoid (CB) products have gained popularity among the public. The anti-inflammatory properties of CBs have piqued…
In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators
Abstract Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are available, neither the X-ray crystal…
New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence
Abstract Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity…
Hepatic Cannabinoid Signaling in the Regulation of Alcohol-Associated Liver Disease
Abstract PURPOSE: The endocannabinoid system has emerged as a key regulatory signaling pathway in the pathophysiology of alcohol-associated liver disease…
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Abstract Post-Traumatic Stress Disorder (PTSD), characterized by re-experiencing, avoidance, negative affect, and impaired memory processing, may develop after traumatic events.…
The CB2 Receptor as a Novel Therapeutic Target for Epilepsy Treatment
Abstract Epilepsy is characterized by repeated spontaneous bursts of neuronal hyperactivity and high synchronization in the central nervous system. It…
Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
Abstract Cannabinoid receptors typically include type 1 (CB1) and type 2 (CB2), and they have attracted extensive attention in the…
The Endocannabinoid System as a Therapeutic Target in Diabetic Peripheral Neuropathic Pain: A Review
Abstract Diabetic peripheral neuropathy (DPN) is characterized by progressive loss of peripheral nerves, which causes numbness, weakness, and severe pain.…