New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence
Abstract Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity…
cannabinoid receptor 1 (CB1R)
Hepatic Cannabinoid Signaling in the Regulation of Alcohol-Associated Liver Disease
Abstract PURPOSE: The endocannabinoid system has emerged as a key regulatory signaling pathway in the pathophysiology of alcohol-associated liver disease…
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Abstract Post-Traumatic Stress Disorder (PTSD), characterized by re-experiencing, avoidance, negative affect, and impaired memory processing, may develop after traumatic events.…
Allosteric Modulation of Cannabinoid Receptor 1—Current Challenges and Future Opportunities
Abstract The cannabinoid receptor type 1 (CB1R), a G protein-coupled receptor (GPCR), plays an essential role in the control of…
Endocannabinoid System and Psychiatry: In Search of a Neurobiological Basis for Detrimental and Potential Therapeutic Effects
Abstract Public concern on mental health has noticeably increased given the high prevalence of neuropsychiatric disorders. Cognition and emotionality are…