Mechanistic origin of partial agonism of tetrahydrocannabinol for cannabinoid receptors
Abstract Cannabinoid receptor 1 (CB1) is a therapeutically relevant drug target for controlling pain, obesity, and other central nervous system…
cannabinoid receptor 1 (CB1)
The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors
Abstract The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased…
The Synaptic Interactions of Alcohol and the Endogenous Cannabinoid System
Abstract PURPOSE: A growing body of evidence has implicated the endocannabinoid (eCB) system in the acute, chronic, and withdrawal effects…
Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment
Abstract Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in…
The Spicy Story of Cannabimimetic Indoles
Abstract The Sterling Research Group identified pravadoline as an aminoalkylindole (AAI) non-steroidal anti-inflammatory pain reliever. As drug design progressed, the…
Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism
Abstract Kratom is a widely abused plant-based drug preparation with a global interest in recent years, well beyond its native…
Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
Abstract Cannabinoid receptors typically include type 1 (CB1) and type 2 (CB2), and they have attracted extensive attention in the…
Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review
Abstract The endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of…
The Endocannabinoid System as a Therapeutic Target in Diabetic Peripheral Neuropathic Pain: A Review
Abstract Diabetic peripheral neuropathy (DPN) is characterized by progressive loss of peripheral nerves, which causes numbness, weakness, and severe pain.…
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB1 receptors
Abstract Background and Purpose: Src homology 3‐domain growth factor receptor‐bound 2‐like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid CB1…