Transcriptional Mapping of the Human Cannabinoid Receptor 1 (CNR1) Gene Promoter
Abstract The transcriptional regulation of the cannabinoid receptor 1 (CB1R) by promoter/enhancer elements and transcription factors is an area of…
cannabinoid receptor 1 (CB1)
Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method
Abstract New psychoactive substances (NPS) targeting cannabinoid receptor 1 pose a significant threat to society as recreational abusive drugs that…
Role of Endocannabinoids in Glaucoma: A Review
Abstract Aims: A review of the published literature was done to understand the role of endocannabinoids in glaucoma. Background: As…
The impact of cannabinoid receptor 1 absence on mouse liver mitochondria homeostasis: insight into mitochondrial unfolded protein response
Abstract Introduction: The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper…
The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update
Abstract The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia…
Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases
Abstract Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective…
Re-evaluation of the cardioprotective effects of cannabinoids against ischemia-reperfusion injury according to the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria
Abstract Ischemic heart disease, associated with high morbidity and mortality, represents a major challenge for the development of drug-based strategies…
Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1
Abstract The cannabinoid receptor 1 (CB1) is famous as the target of Δ9-tetrahydrocannabinol (THC), which is the active ingredient of…
Effects of Cannabis Exposure on Adolescent Health and Development: A Narrative Review
Abstract Adolescence is an immature but adventurous time period of exploration. Due to rapid developments of the brain with unbalanced…
Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor
Abstract The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive substances has posed considerable public health risks, including…