Impact of the Cannabinoid System in Alzheimer’s Disease
Abstract Cannabinoids are compounds isolated from cannabis and are also widely present in both nervous and immune systems of animals.…
cannabinoid CB2 receptor
β-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly via CB2 and Non-CB2 Receptor Mechanisms
Abstract Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward and addiction. However, it is unclear…
Effects of Cannabidiol and Beta-Caryophyllene Alone or in Combination in a Mouse Model of Permanent Ischemia
Abstract Current treatments for stroke, which account for 6.5 million global deaths annually, remain insufficient for treatment of disability and…
Possible Receptor Mechanisms Underlying Cannabidiol Effects on Addictive-like Behaviors in Experimental Animals
Abstract Substance use disorder (SUD) is a serious public health problem worldwide for which available treatments show limited effectiveness. Since…
CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing
Abstract The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in…
Administration of Δ9‐Tetrahydrocannabinol (THC) Post‐Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity
Abstract Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication that can ensue following Staphylococcus aureus infection. The enterotoxin produced…
The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases
Abstract Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the…
The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?
Abstract The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last decade. The immense data load…
4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation
Abstract Background and purpose: 4′-O-methylhonokiol (MH) is a natural product showing anti-inflammatory, anti-osteoclastogenic, and neuroprotective effects. MH was reported to…