Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs
Abstract Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam and in late 2021 arose on the…
cannabinoid CB1 receptor
Impact of the Cannabinoid System in Alzheimer’s Disease
Abstract Cannabinoids are compounds isolated from cannabis and are also widely present in both nervous and immune systems of animals.…
Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression
Abstract Cannabidiol (CBD) is a potential antidepressant agent. We examined the association between the antidepressant effects of CBD and alterations…
Hippocampal Deletion of CB1 Receptor Impairs Social Memory and Leads to Age-Related Changes in the Hippocampus of Adult Mice
Abstract Endocannabinoid system activity declines with age in the hippocampus, along with the density of the cannabinoid receptor type-1 (CB1).…
Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge
Abstract Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders…
Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018
Abstract Neutral antagonists of GPCRs remain relatively rare—indeed, a large majority of GPCR antagonists are actually inverse agonists. The synthetic…
N-Acyl Dopamines Induce Apoptosis in Endometrial Stromal Cells from Patients with Endometriosis
Abstract Endometriosis is characterized by the formation and development of endometrial tissues outside the uterus, based on an imbalance between…
Chlorpyrifos and Δ9 Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity
Keywords: Chlorpyrifos, Endocannabinoids, CB1 receptor, Microbiota, Obesogen, Δ Authors: Marilyn H. Silva License: © 2021 The Author(s) CC BY-NC-ND 4.0…
Regulation of stress-provoked aggressive behavior using endocannabinoids
Abstract Reactive impulsive aggression is characterized by outbursts of rage and violence when subjects encounter threatening stressful events. Although impulsive…
Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors
Abstract Cannabis (marijuana) has been known to humans for thousands of years but its neurophysiological effects were sparsely understood until…