Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors
Abstract Cannabis (marijuana) has been known to humans for thousands of years but its neurophysiological effects were sparsely understood until…
cannabinoid CB1 receptor
Characterization of Subtype Selective Cannabinoid CB2 Receptor Agonists as Potential Anti-Inflammatory Agents
Abstract Activation of the CB2 receptor has been shown to have anti-inflammatory and antinociceptive effects without causing psychoactive effects. Previously,…
Dichotomic Hippocampal Transcriptome After Glutamatergic vs. GABAergic Deletion of the Cannabinoid CB1 Receptor
Abstract Brain homeostasis is the dynamic equilibrium whereby physiological parameters are kept actively within a specific range. The homeostatic range…
Possible Receptor Mechanisms Underlying Cannabidiol Effects on Addictive-like Behaviors in Experimental Animals
Abstract Substance use disorder (SUD) is a serious public health problem worldwide for which available treatments show limited effectiveness. Since…
CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing
Abstract The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in…
Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities
Abstract Objective: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate…
The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases
Abstract Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the…
Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome
Abstract In this review, we discuss the role of the endocannabinoid (eCB) system in regulating energy and metabolic homeostasis. Endocannabinoids,…
Structural Insights into CB1 Receptor Biased Signaling
Abstract The endocannabinoid system has emerged as a promising target for the treatment of numerous diseases, including cancer, neurodegenerative disorders,…
The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?
Abstract The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last decade. The immense data load…