Are Cannabis-Based Medicines a Useful Treatment for Neuropathic Pain? A Systematic Review
Abstract Neuropathic pain is a chronic disorder that arises from damaged or malfunctioning nerves. Hypersensitivity to stimuli, also known as…
cannabidivarin
Genotoxicity of selected cannabinoids in human lymphoblastoid TK6 cells
Abstract Natural non-psychoactive cannabinoids such as cannabigerol (CBG), cannabidiol (CBD), cannabichromene (CBC), cannabidivarin (CBDV), and cannabinol (CBN) are increasingly consumed…
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells
Abstract Cannabidivarin (CBDV) and cannabigerol (CBG) are minor phytocannabinoids from Cannabis sativa, whose health benefits have been reported. However, studies…
Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia
Abstract Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that regulates the activation of immune cells, which is a…
Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype
Abstract Although cannabinoids have been used for centuries for diverse pathological conditions, recently, their clinical interest and application have emerged…
An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
Abstract Cannabis contains more than 100 phytocannabinoids. Most of these remain poorly characterized, particularly in neurons. We tested a panel…
Protective Effects of Cannabidivarin and Cannabigerol on Cells of the Blood–Brain Barrier Under Ischemic Conditions
Abstract Background and Objectives: Preclinical studies have shown cannabidiol is protective in models of ischemic stroke. Based on results from…
Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin
Abstract Background: Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms…
Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?
Abstract Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental disorders that cause high levels of functional disabilities. Also, the…
Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…