CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons
Abstract Introduction: Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain.…
Cannabidiol (CBD)
Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract
Abstract Cannabidiol (CBD)-rich hemp extract use is increasing in veterinary medicine with little examination of serum cannabinoids. Many products contain…
Towards Better Delivery of Cannabidiol (CBD)
Abstract Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective drug by the pharmaceutical industry is hindered…
Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies
Abstract The etiopathogenesis of autism spectrum disorder (ASD) remains largely unclear. Among other biological hypotheses, researchers have evidenced an imbalance…
Anti-proliferative and cytotoxic effect of cannabidiol on human cancer cell lines in presence of serum
Abstract Objective: Cannabinoids are able to reduce tumor growth in xenograft models, but their therapeutic potential as anti-cancer drugs in…
Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures were eliminated by cannabidiol
Abstract We observed that cannabidiol supplements were highly effective in treating an infant boy with drug-resistant early infantile epileptic encephalopathy,…
The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model
Abstract Background: Few models exist that can control for placebo and expectancy effects commonly observed in clinical trials measuring ‘Cannabis’…
Advances in Neurobiology and Pharmacology of GPR12
Abstract GPR12 is a G protein-coupled orphan receptor genetically related to type 1 and type 2 cannabinoid receptors (CB1 and…
A Case of Toxicity from Cannabidiol Gummy Ingestion
Abstract A 56-year-old male with no known history of substance abuse and no known prior medical conditions presented via ambulance…
Cannabinoids, Blood–Brain Barrier, and Brain Disposition
Abstract Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics,…