Therapeutic Potential of Minor Cannabinoids in Dermatological Diseases—A Synthetic Review
Abstract Dermatological diseases pose a significant burden on the quality of life of individuals and can be challenging to treat…
cannabidavarin (CBDV)
Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial
Abstract Objective: Rett syndrome (RTT), commonly caused by methyl‐CpG‐binding protein 2 (MECP2) pathogenic variants, has many comorbidities. Fifty to ninety…
Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin
Abstract Background: Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms…
Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances
Abstract Epilepsy is a neurological disorder mainly characterised by recurrent seizures that affect the entire population diagnosed with the condition.…
Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…
Structure–Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives
Abstract Background: As a library of cannabinoid (CB) derivatives with (-)-trans-cannabidiol (CBD) or (-)-trans-cannabidivarin (CBDV) scaffold, we synthesized nine novel…
Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells
Abstract Electronic supplementary material: The online version of this article (10.1007/s00204-018-2322-9) contains supplementary material, which is available to authorized users.…