FOXD1 expression in head and neck squamous carcinoma: a study based on TCGA, GEO and meta-analysis
Abstract Forkhead box D1 (FOXD1) is a new member of FOX transcription factor family. FOXD1 has demonstrated multilevel roles during…
Cancer prognosis
Pan-Cancer Survival Classification With Clinicopathological and Targeted Gene Expression Features
Abstract Prognostication for patients with cancer is important for clinical planning and management, but remains challenging given the large number…
The role of YTH domain containing 2 in epigenetic modification and immune infiltration of pan‐cancer
Abstract YTH domain containing 2 (YTHDC2) is the largest N6‐Methyladenosine (m6A) binding protein of the YTH protein family and the…
The functions and prognostic values of m6A RNA methylation regulators in thyroid carcinoma
Abstract Background: N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression…
LncRNA AC007255.1, an immune-related prognostic enhancer RNA in esophageal cancer
Abstract Background: Growing evidence has suggested that enhancer RNAs (eRNAs), a set of long non-coding RNAs (lncRNAs) that were derived…
Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model
Abstract Background: Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an…
Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)
Abstract Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like…
A Comprehensive Pan-Cancer Analysis of 33 Human Cancers Reveals the Immunotherapeutic Value of Aryl Hydrocarbon Receptor
Abstract Background: Previous studies have reported the potential of aryl hydrocarbon receptor (AhR) in cancer immunotherapy. However, the mechanisms underpinning…
SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00262-021-02995-4. Article type: Research Article Keywords: Surfactant protein A1,…
Simultaneous Expression of Long Non-Coding RNA FAL1 and Extracellular Matrix Protein 1 Defines Tumour Behaviour in Young Patients with Papillary Thyroid Cancer
Abstract Simple Summary: FAL1 upregulation has been reported in many types of human cancers. The up-regulatory mechanism was identified in…