A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors
Abstract Objective: We performed a pan-cancer analysis to explore the potential mechanisms of FAT4 in 33 different tumors. Methods: In…
Cancer prognosis
A comprehensive prognostic and immunological analysis of ephrin family genes in hepatocellular carcinoma
Abstract Background: Ephrins, a series of Eph-associated receptor tyrosine kinase ligands, play an important role in the tumorigenesis and progression…
Identification of OTUD6B as a new biomarker for prognosis and immunotherapy by pan-cancer analysis
Abstract Background: Ovarian-tumor (OTU) domain-containing protein 6B (OTUD6B), one of newly identified OTU deubiquitylating enzyme families, is proved to be…
LncRNA DUXAP8 as a prognostic biomarker for various cancers: A meta-analysis and bioinformatics analysis
Abstract Background: Dual homeoboxes A pseudogene 8 (DUXAP8) is a newly discovered long noncoding RNA that has been shown to…
Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB
Abstract It is well-established that SPIB is essential for the survival of mature B cells, playing a key role in…
The epiphany derived from T-cell–inflamed profiles: Pan-cancer characterization of CD8A as a biomarker spanning clinical relevance, cancer prognosis, immunosuppressive environment, and treatment responses
Abstract CD8A encodes the CD8 alpha chain of αβT cells, which has been proposed as a quantifiable indicator for the…
Pan-cancer analyses and molecular subtypes based on the cancer-associated fibroblast landscape and tumor microenvironment infiltration characterization reveal clinical outcome and immunotherapy response in epithelial ovarian cancer
Abstract Background: Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment (TME). These cells play a supportive role throughout…
A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear Cell Carcinoma
Abstract Blood group antigen is a class of heritable antigenic substances present on the erythrocyte membrane. However, the role of…
A systematic pan-cancer analysis of the gasdermin (GSDM) family of genes and their correlation with prognosis, the tumor microenvironment, and drug sensitivity
Abstract Background: Pyroptosis is a programmed cell death process mediated by the gasdermin (GSDM) protein. However, limited research has been…
Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer
Abstract Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the…