NALCN is a potential biomarker and therapeutic target in human cancers
Abstract Background: Sodium leak channel non-selective (NALCN), known as a voltage-independent Na+ channel, is increasingly considered to play vital roles…
Cancer prognosis
Integration of Chemoinformatics and Multi-Omics Analysis Defines ECT2 as a Potential Target for Cancer Drug Therapy
Abstract Simple Summary: Cancer is a leading cause of death worldwide and continuous efforts are exerted to develop novel biomarkers…
EZH2 as a prognostic-related biomarker in lung adenocarcinoma correlating with cell cycle and immune infiltrates
Abstract Backgrounds: It has been observed that high levels of enhancer of zeste homolog 2 (EZH2) expression are associated with…
A pan-cancer analysis of the oncogenic role of YKT6 in human tumors
Abstract YKT6, as a Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein with vesicle trafficking, plays an essential role in…
Oncogenic role of copper‑induced cell death‑associated protein DLD in human cancer: A pan‑cancer analysis and experimental verification
Abstract Copper ions can bind directly to lipoylated components of the tricarboxylic acid (TCA) cycle, triggering the aggregation of mitochondrial…
The prognostic and immunological role of MYB: from bladder cancer validation to pan-cancer analysis
Abstract Background: MYB proto-oncogene is verified as a transcription factor. Although emerging evidence showed that MYB plays a critical part…
Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis
Abstract Background: Nonerythrocytic spectrin beta 1 (SPTBN1) is an important cytoskeletal protein that involves in normal cell growth and development…
Comprehensive analysis of the cuproptosis-related gene DLD across cancers: A potential prognostic and immunotherapeutic target
Abstract DLD is a key gene involved in “cuproptosis,” but its roles in tumor progression and immunity remain unclear. Exploring…
Integrated pancancer analysis reveals the oncogene characteristics and prognostic value of DIP2B in breast cancer
Abstract Background: Disco-interaction protein 2 homologue B (DIP2B) plays an important role in DNA methylation. There have been many reports…
ORC6, a novel prognostic biomarker, correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis
Abstract Background: The origin recognition complex (ORC), a six-subunit DNA-binding complex, participates in DNA replication in cancer cells. Specifically in…