Exploration of the carcinogenetic and immune role of CHK1 in human cancer
Abstract Background: Previous study indicated that CHK1 was important for repairing DNA damage and cell cycle regulation. Aims: To investigate…
Cancer prognosis
Disulfidptosis: A New Target for Parkinson’s Disease and Cancer
Abstract Recent studies have uncovered intriguing connections between Parkinson’s disease (PD) and cancer, two seemingly distinct disease categories. Disulfidptosis has…
Prognostic and Immunological Role of Cuproptosis-Related Gene MTF1 in Pan-Cancer
Abstract Metal regulatory transcription factor 1 (MTF1) has been reported to induce the expression of metallothionein and other genes involved…
Pan-cancer analysis of the role of α2C-adrenergic receptor (ADRA2C) in human tumors and validation in glioblastoma multiforme models
Abstract Background: Several studies have reported the relationship between α2C-adrenergic receptor (ADRA2C) and both neoplastic and non-neoplastic diseases. However, a…
Deciphering the multidimensional impact of IGFBP1 expression on cancer prognosis, genetic alterations, and cellular functionality: A comprehensive Pan-cancer analysis
Abstract Objectives: IGF-binding protein 1 (IGFBP1) is a key regulator of insulin-like growth factors, impacting biological processes, including cancer progression…
Construction of thyroid cancer classification and iodine metabolism related diagnostic model using thyroid differentiation score and bioinformation
Abstract To more accurately diagnose and treat patients with different subtypes of thyroid cancer, we constructed a diagnostic model related…
SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation
Abstract SPRED3 (Sprouty-related EVH1 domain containing 3) mutants are depicted in various cancers, however, nothing is known about its biofunction…
A pan-cancer analysis of the association of METRN with prognosis and immune infiltration in human tumors
Abstract Background: Meteorin (METRN) is expressed predominantly in the central nervous system (CNS), where it functions by regulating glial cell…
Comprehensive pan-cancer analysis reveals EPHB2 is a novel predictive biomarker for prognosis and immunotherapy response
Abstract Purpose: Recent studies have increasingly linked Ephrin receptor B2 (EPHB2) to cancer progression. However, comprehensive investigations into the immunological…
Pan-cancer analysis suggests that LY6H is a potential biomarker of diagnosis, immunoinfiltration, and prognosis
Abstract LY6H, a member of the lymphocyte antigen-6(LY6) gene family, is located on human chromosomes 6, 8, 11 and 19.…