Cancer cachexia: molecular basis and therapeutic advances
Abstract The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis…
Cancer microenvironment
CD58 reshapes the immunosuppressive microenvironment in gliomas through PD-L1 upregulation
Abstract Background: Cluster of Differentiation 58 (CD58), a critical immune regulator, is implicated in tumor immune evasion, yet its role…
Eosinophil extracellular traps formation is correlated with cancer prognosis by tumor microenvironment remodeling
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-24010-x. Article type: Research Article Keywords: Eosinophil, Eosinophil extracellular…
Multidimensional analysis reveals the potential of ACSL3 as a cancer biomarker: from pan-cancer exploration to functional validation in hepatocellular carcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10238-025-01882-x. Article type: Research Article Keywords: ACSL3, Pan-cancer analysis,…
p53 and PD-1/PD-L1 expression contribute to disease progression and are correlated to immune infiltrates in urothelial carcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-19897-5. Article type: Research Article Keywords: PD-1/PD-L1, Urothelial carcinoma,…
Cholesterol modified defense peptide as an EMP2-siRNA delivery system for synergistic immunogene therapy against breast cancer
Abstract Epithelial membrane protein 2 (EMP2) plays crucial roles in cell proliferation, migration, and adhesion. Despite its importance, conventional EMP2…
Single-cell transcriptomics analysis reveals a disrupted NK-T cell interaction network in liver metastatic cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-06241-0. Article type: Research Article Keywords: NK-T interaction, Liver…
Pan-cancer analysis of oncogenic role of MAGOH and experiment validation in hepatocellular carcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-08678-9. Article type: Research Article Keywords: MAGOH (Mago-nashi homolog),…
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
Abstract Loss of the Y chromosome (LOY) in peripheral blood mononuclear cells (PBMCs) is the most common somatic alteration in…
Multi-omic analyses reveal PTPN6’s impact on tumor immunity across various cancers
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-96302-1. Article type: Research Article Keywords: Cancer genomics, Cancer…