Monoamine Oxidase B in Cancers: Implications for Therapeutics and Prognosis
Abstract Monoamine oxidase B (MAOB) is an enzyme implicated in various physiological and pathological processes, particularly in the context of…
cancer metabolism
LCAT in Cancer Biology: Embracing Epigenetic Regulation, Immune Interactions, and Therapeutic Implications
Abstract Lecithin cholesterol acyltransferase (LCAT) is a crucial enzyme in high-density lipoprotein (HDL) metabolism that is often dysregulated in cancers,…
Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma
Abstract Recurring evidence suggests that fasting has extensive antitumor effects in various cancers, including papillary thyroid carcinoma (PTC). However, the…
Comprehensive Analysis for Anti-Cancer Target-Indication Prioritization of Placental Growth Factor Inhibitor (PGF) by Use of Omics and Patient Survival Data
Abstract Simple Summary: Recognized as a promising target for anti-cancer treatment, PGF has the potential to overcome resistance to existing…
Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
Abstract Background: B-raf inhibitors (BRAFi) are effective for BRAF-mutated papillary (PTC) and anaplastic (ATC) thyroid carcinomas, although acquired resistance impairs…
Unique Metabolic Contexts Sensitize Cancer Cells and Discriminate between Glycolytic Tumor Types
Abstract Simple Summary: We sought to assess cancer cell viability in the context of glycolytic versus oxidative phosphorylation carbon source…
Peroxisome Metabolism in Cancer
Abstract Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redox balance. Peroxisomal function is central to fatty acid…