Comprehensive analysis on the implications of IAH1 in cancer development and progression
Abstract Objective: This study aimed to elucidate the role of the IAH1 gene across multiple cancer types. Methods: Using multi-omics…
cancer immunotherapy
CD93 in Health and Disease: Bridging Physiological Functions and Clinical Applications
Abstract CD93 is a highly glycosylated transmembrane glycoprotein with key functional domains, including a C-type lectin-like domain (CTLD) and epidermal…
The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response
Abstract Background: Melanoma is one of the most serious skin cancers worldwide, often progressing without obvious symptoms. Early detection is…
Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for thyroid cancer
Abstract Background: Thyroid cancer (THCA) exhibits high molecular heterogeneity, posing challenges for precise prognosis and personalized therapy. Most existing models…
A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors
Abstract Introduction: Natural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and…
Multi-omics analysis reveals cancer stemness function and establishes a predictive model for thyroid cancer prognosis and immunotherapy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-02813-8. Article type: Research Article Keywords: Cancer stemness, Immunotherapy,…
Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages
Abstract Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple…
Thyroid hormone receptor interacting protein 13 is associated with prognosis and immunotherapy efficacy in human cancers: a pan-cancer analysis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-02385-7. Article type: Research Article Keywords: Cancer immunotherapy, Cancer…
Comprehensive pan-cancer analysis of PPP1R3G reveals its diagnostic, prognostic, and immunotherapeutic implications
Abstract Background: PPP1R3G, a regulatory subunit of protein phosphatase 1, plays a critical role in glycogen metabolism and has been…
NCBP2 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis
Abstract Background: The cap-binding complex (CBC) plays a crucial role in facilitating gene expression by safeguarding mRNA from nonsense-mediated decay,…