Regulation, genomics, and clinical characteristics of cuproptosis regulators in pan-cancer
Abstract Background: Cuproptosis, a copper-dependent controlled cell death, is a novel form of cell death that differs from known cell…
Cancer epigenomics
Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function
Abstract Glycosylation is a fundamental cellular process affecting human development and health. Complex machinery establishes the glycan structures whose heterogeneity…
Multi-omics analysis reveals the panoramic picture of necroptosis-related regulators in pan-cancer
Abstract Background: Unlike apoptosis, necroptosis is a tightly regulated form of programmed cell death (PCD) that occurs in a caspase-independent…
Comprehensive Analysis of the Expression and Prognosis for the DREAM Complex in Human Cancers
Abstract The DREAM complex is an evolutionarily conserved cell cycle regulating multi-protein complex. In addition to playing an essential function…
Recent advances in Cannabis sativa genomics research
Abstract Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have unique medicinal properties. However, scientific…
Pan-cancer analysis of differential DNA methylation patterns
Abstract Background: DNA methylation is a key epigenetic regulator contributing to cancer development. To understand the role of DNA methylation…
Absence of an embryonic stem cell DNA methylation signature in human cancer
Abstract Background: Differentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory…
Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers
Abstract It has been proposed that the circadian rhythm generally plays important roles in tumor suppression, but there is also…
The early pregnancy placenta foreshadows DNA methylation alterations of solid tumors
Abstract The placenta relies on phenotypes that are characteristic of cancer to successfully implant the embryo in the uterus during…
Epigenetic Interactions between Alcohol and Cannabinergic Effects: Focus on Histone Modification and DNA Methylation
Abstract Epigenetic studies have led to a more profound understanding of the mechanisms involved in chronic conditions. In the case…