SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation
Abstract SPRED3 (Sprouty-related EVH1 domain containing 3) mutants are depicted in various cancers, however, nothing is known about its biofunction…
Cancer epigenetics
Genetic Characterization and Chemical Identification of Moroccan Cannabis sativa (L.) Seeds: Extraction, and In Vitro and In Silico Biological Evaluation
Abstract This study investigated the molecular, phytochemical, and biological aspects of ten local Moroccan traditional landrace Cannabis seeds. Genetic polymorphisms…
Detection of closely linked QTLs and candidate genes controlling germination indices in response to drought and salinity stresses in barley
Abstract The aim of current study was to identify closely linked QTLs and candidate genes related to germination indices under…
Homeobox and Polycomb target gene methylation in human solid tumors
Abstract DNA methylation is an epigenetic mark that plays an important role in defining cancer phenotypes, with global hypomethylation and…
Epigenetic Regulation of DLK1-DIO3 Region in Thyroid Carcinoma
Abstract Non-coding RNAs (ncRNAs) have emerged as pivotal regulators in cellular biology, dispelling their former perception as ‘junk transcripts’. Notably,…
Comparative restriction enzyme analysis of methylation (CREAM) reveals methylome variability within a clonal in vitro cannabis population
Abstract The primary focus of medicinal cannabis research is to ensure the stability of cannabis lines for consistent administration of…
Novel T cell exhaustion gene signature to predict prognosis and immunotherapy response in thyroid carcinoma from integrated RNA-sequencing analysis
Abstract Exhausted CD8+ T lymphocytes and tumor-associated macrophages play critical roles in determining cancer prognosis and the efficacy of immunotherapy.…
Pan-cancer analyses of senescence-related genes in extracellular matrix characterization in cancer
Abstract Purpose: The aged microenvironment plays a crucial role in tumor onset and progression. However, it remains unclear whether and…
CRISPR–Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames
Abstract Emerging evidence suggests that cryptic translation beyond the annotated translatome produces proteins with developmental or physiological functions. However, functions…
Integrated multiomics analysis of chromosome 19 miRNA cluster in bladder cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10142-023-01191-0. Article type: Research Article Keywords: Cancer biomarker, Epigenetics,…