ASAP1 Promotes Epithelial to Mesenchymal Transition by Activating the TGFβ Pathway in Papillary Thyroid Cancer
Abstract Background: Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy. While the prognosis of PTC is…
cancer cell invasion
ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling
Abstract Triple‐negative breast cancer (TNBC) is highly metastatic and presents clinical challenges given the lack of targeted therapies. Here, we…
TGFBR3 inhibits progression of papillary thyroid cancer by inhibiting the PI3K/AKT pathway and EMT
Abstract Background: Transforming growth factor beta receptor III (TGFBR3) has been shown to play a tumor-suppressive role in a variety…
High expression of COL8A1 predicts poor prognosis and promotes EMT in papillary thyroid cancer
Abstract Background: Collagen type VIII α 1 chain (COL8A1), a collagen type VIII protein, has been suggested to exert various…
Elevated ITGA3 expression serves as a novel prognostic biomarker and regulates tumor progression in cervical cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-75770-x. Article type: Research Article Keywords: ITGA3, Cervical cancer,…
Pan-cancer analysis of the role of α2C-adrenergic receptor (ADRA2C) in human tumors and validation in glioblastoma multiforme models
Abstract Background: Several studies have reported the relationship between α2C-adrenergic receptor (ADRA2C) and both neoplastic and non-neoplastic diseases. However, a…
Aberrant RBMX expression is relevant for cancer prognosis and immunotherapy response
Abstract Cancer accounts for the highest rates of morbidity and mortality worldwide. RNA binding motif protein X-linked (RBMX) is a…
Agrin is a novel oncogenic protein in thyroid cancer
Abstract Agrin (AGRN) is a matricellular glycoprotein involved in extracellular signal transduction. AGRN is involved in tumorigenesis and cancer progression;…
Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3
Abstract Arap3, a dual GTPase-activating protein (GAP) for the small GTPases Arf6 and RhoA, plays key roles in regulating a…
Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer
Abstract Introduction: Several studies have shown anti-tumor effects of components present in cannabis in different models. Unfortunately, little is known…