CaMKII

January 18, 2022

CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms

Abstract Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition that can cause fatal cardiac arrhythmia. Human mutations in the…

May 7, 2021

TBK1 interacts with tau and enhances neurodegeneration in tauopathy

Abstract One of the defining pathological features of Alzheimer’s disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of…

December 13, 2016

Targeting calcium signaling in cancer therapy

Abstract The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating…