Cuproptosis: a promising new target for breast cancer therapy
Abstract Breast cancer (BC) is the leading cause of cancer-related mortality among women globally, affecting approximately one-quarter of all female…
bone metastasis
Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10238-024-01515-9. Article type: Research Article Keywords: Circulating hybrid cells,…
The molecular anti-metastatic potential of CBD and THC from Lebanese Cannabis via apoptosis induction and alterations in autophagy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-76340-x. Article type: Research Article Keywords: Breast cancer, Cannabinoids,…
Interleukin-1 Receptor-Associated Kinase 1 in Cancer Metastasis and Therapeutic Resistance: Mechanistic Insights and Translational Advances
Abstract Interleukin-1 Receptor Associated Kinase 1 (IRAK1) is a serine/threonine kinase that plays a critical role as a signaling transducer…
Unveiling the Uncommon: Ovarian Cancer Metastasis as a Rare Cause of Obstructive Jaundice and Partial Gastric Outlet Obstruction
Abstract Ovarian malignancy leading to liver metastasis is relatively common in advanced stages; however, metastasis causing partial gastric outlet obstruction…
The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway
Abstract SASH1 (SAM and SH3 domain containing 1) has been increasingly reported as a tumor suppressor gene. However, there is…
Prognostic and Therapeutic Implications of Cell Division Cycle 20 Homolog in Breast Cancer
Abstract Simple Summary: In breast cancer (BC), the triple-negative breast cancer subtype, the upregulation of CDC20 is positively associated with…
Exploring the role of trifarotene against RAR-α: an investigation of expression pattern and clinicopathological significance of RAR-α in breast cancer
Abstract Introduction: The members retinoic acid receptors (RARs) (α, β, and γ) and retinoid X receptors (RXRs) (α, β, and…
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target
Abstract Purpose: Pancreatic cancer (PC) is a highly malignant tumor that poses a severe threat to human health. Brain glycogen…
HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma
Abstract Graphical Abstract: Supplementary Information: The online version contains supplementary material available at 10.1186/s12967-023-04538-0. Article type: Research Article Keywords: Anaplastic…