Plasma cannabinoid concentrations and transference during long-term industrial hemp administration in cattle
Abstract With recent legalization of industrial hemp (IH) production and increased interest in including IH and its byproducts in cattle…
blood plasma
Does acute stress induced via cold water immersion increase blood THC concentrations in regular cannabis users?
Abstract Rationale: Δ9-tetrahydrocannabinol (THC), the principal intoxicant in cannabis, is a highly lipophilic substance that is readily stored in fat.…
Uncovering metabolic dysregulation in schizophrenia and cannabis use disorder through untargeted plasma lipidomics
Abstract Cannabis use disorder affects up to 42% of individuals with schizophrenia, correlating with earlier onset, increased positive symptoms, and…
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice
Abstract Background: Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in…
Bidirectional Effect of Long-Term Δ9-Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome
Abstract Brain aging is associated with cognitive decline, reduced synaptic plasticity, and altered metabolism. The activity of mechanistic target of…
Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol
Abstract Chronic UV radiation causes oxidative stress and inflammation of skin and blood cells. Therefore, in this study, we assessed…
Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol
Abstract UVA/UVB radiation disturbs the redox balance of skin cells, and metabolic consequences can be transferred into the blood and…
A validated UHPLC-MS/MS method for rapid determination of senicapoc in plasma samples
Abstract The clinically tested KCa3.1 channel blocker, senicapoc, has been proven to have excellent pharmacological properties and prior clinical trials…
Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion
Abstract Background: The transient global cerebral hypoperfusion/reperfusion achieved by induction of Bilateral Common Carotid Artery Occlusion followed by Reperfusion (BCCAO/R)…