Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer
Abstract Background: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a 20% recurrence rate. Bitter taste receptors…
biphasic calcium phosphates
Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity
Abstract Cortical pathology involving inflammatory and neurodegenerative mechanisms is a hallmark of multiple sclerosis and a correlate of disease progression…
Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer’s Disease
Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease and the most frequent cause of progressive dementia in senior adults.…
The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model
Abstract Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol (THC); however, up to 120 types of…
Anti-Inflammatory Effects of Cannabigerol in Rheumatoid Arthritis Synovial Fibroblasts and Peripheral Blood Mononuclear Cell Cultures Are Partly Mediated by TRPA1
Abstract Since its medical legalization, cannabis preparations containing the major phytocannabinoids (cannabidiol (CBD) and δ9-tetrahydrocannabinol (THC)) have been used by…
Suppression of Calcium Entry Modulates the Expression of TRβ1 and Runx2 in Thyroid Cancer Cells, Two Transcription Factors That Regulate Invasion, Proliferation and Thyroid-Specific Protein Levels
Abstract Simple Summary: Thyroid cancer is the most common endocrine cancer and the treatment for such hostile tumors remains a…
Structure and function of the N-terminal extension of the formin INF2
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00018-022-04581-y. Article type: Research Article Keywords: INF2, Formins, Calmodulin,…
Cannabidiol prevents methamphetamine-induced neurotoxicity by modulating dopamine receptor D1-mediated calcium-dependent phosphorylation of methyl-CpG-binding protein 2
Abstract In the past decade, methamphetamine (METH) abuse has sharply increased in the United States, East Asia, and Southeast Asia.…
Functional characterization of cannabidiol effect on the serotonergic neurons of the dorsal raphe nucleus in rat brain slices
Abstract Cannabidiol (CBD), the main non-psychoactive cannabinoid found in the cannabis plant, elicits several pharmacological effects via the 5-HT1A receptor.…
Chemical shift assignments of calmodulin bound to a C-terminal site (residues 1120–1147) in the β-subunit of a retinal cyclic nucleotide-gated channel (CNGB1)
Abstract Retinal cyclic nucleotide-gated (CNG) channels consist of two protein subunits (CNGA1 and CNGB1). Calmodulin (CaM) binds to two separate…