Spindle component 25 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis
Abstract Spindle component 25 (SPC25) is one of the four proteins that make up the nuclear division cycle 80 (NDC80)…
biomarkers
Tubulin alpha-1b chain was identified as a prognosis and immune biomarker in pan-cancer combing with experimental validation in breast cancer
Abstract The α-tubulin subtype, Tubulin α-1b chain (TUBA1B), has been shown to influence immune cell infiltration, cancer growth, and survival…
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-024-01758-3. Article type: Research Article Keywords: Cerebrospinal fluid, Biomarkers,…
Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies
Abstract Objective: To identify imaging subtypes of the cortico-basal syndrome (CBS) based solely on a data-driven assessment of MRI atrophy…
Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker
Abstract Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating…
Pan-cancer integrated analysis of ANKRD1 expression, prognostic value, and potential implications in cancer
Abstract There is substantial evidence demonstrating the crucial role of inflammation in oncogenesis. ANKRD1 has been identified as an anti-inflammatory…
Taurohyocholic acid acts as a potential predictor of the efficacy of tyrosine kinase inhibitors combined with programmed cell death-1 inhibitors in hepatocellular carcinoma
Abstract Background and aims: Tyrosine kinase inhibitors (TKIs) combined with programmed cell death protein-1 (PD-1) have significantly improved survival in…
Pan-caner analysis identifies PSMA7 as a targets for amplification at 20q13.33 in tumorigenesis
Abstract The chromosome 20 long arm (20q) is one of the genomic hotspots where copy number alterations frequently occur in…
Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms
Abstract Background: The endocannabinoid (eCB) system and the serotonin (5-HT) are both implicated in the severity of the depression. 5-HT…
Comprehensive analysis of the potential biological significance of cuproptosis-related gene LIPT2 in pan-cancer prognosis and immunotherapy
Abstract Lipoyltransferase 2 (LIPT2) acts as a key enzyme involved in fatty acid metabolism and cell membrane synthesis. However, the…