MAPK13 promotes the progression of papillary thyroid cancer
Abstract Objective: This study aims to analyze the genes that influence PTC progression and investigate the role of MAPK13 in…
Biomarker cancer progression
GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner
Abstract Background: Thyroid cancer, the most prevalent endocrine malignancy, poses significant therapeutic challenges due to its heterogeneous biological behavior. Growth…
ACOXL-AS1’s pan-cancer dynamics and its proliferative impact on endometrial endometrioid carcinoma
Abstract Background: Long non-coding RNAs (lncRNAs) are critically involved in carcinogenesis; however, the pan-cancer significance and functional mechanisms of ACOXL-AS1…
The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer
Abstract Introduction: Aldo-keto reductase 1B10 (AKR1B10) is a multifunctional enzyme, which is important in cancer development and progression, but the…
METTL protein family: focusing on the occurrence, progression and treatment of cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40364-024-00652-3. Article type: Review Article Keywords: METTL protein family,…
Multifaceted roles and functions of SOX30 in human cancer
Abstract SRY‐box transcription factor 30 (SOX30) participates in tumor cell apoptosis in lung cancer. The occurrence of somatic SOX30 mutations,…
COL4A2 enhances thyroid cancer cell proliferation through the AKT pathway
Abstract Objectives: Thyroid cancer (THCA) is the most common malignant tumor in endocrine system and the incidence has been increasing…
An Observatory for the MET Oncogene: A Guide for Targeted Therapies
Abstract Simple Summary: The MET gene encodes a receptor critical for cell growth and repair. It plays diverse roles in…
Mitochondrial Ribosomal Protein L14 Promotes Cell Growth and Invasion by Modulating Reactive Oxygen Species in Thyroid Cancer
Abstract Objectives: The mitochondrial ribosomal protein L14 (MRPL14) is encoded by a nuclear gene and participates in mitochondrial protein translation.…
NKD2 is correlated with the occurrence, progression and prognosis of thyroid carcinoma
Abstract Background: Thyroid carcinoma (THCA) is the most prevalent type of tumor in endocrine system. NKD2 has been increasingly evidenced…