Distinct dosage compensations of ploidy-sensitive and -insensitive X chromosome genes during development and in diseases
Abstract The active X chromosome in mammals is upregulated to balance its dosage to autosomes during evolution. However, it is…
Biological sciences
Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant
Abstract Epilepsy and neurodevelopmental disorders can arise from pathogenic variants of KCNQ (Kv7) channels. A patient with developmental and epileptic…
Cannabis sativa research trends, challenges, and new-age perspectives
Abstract Cannabis sativa L. has been one of the oldest medicinal plants cultivated for 10,000 years for several agricultural and…