Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target
Abstract Purpose: Pancreatic cancer (PC) is a highly malignant tumor that poses a severe threat to human health. Brain glycogen…
bioinformatics analysis
Prognostic value and immunological role of PD-L1 gene in pan-cancer
Abstract Objective: PD-L1, a target of immune checkpoint blockade, has been proven to take the role of an oncogene in…
Exploration and validation of key genes associated with early lymph node metastasis in thyroid carcinoma using weighted gene co-expression network analysis and machine learning
Abstract Background: Thyroid carcinoma (THCA), the most common endocrine neoplasm, typically exhibits an indolent behavior. However, in some instances, lymph…
The comprehensive analysis of the prognostic and functional role of N-terminal methyltransferases 1 in pan-cancer
Abstract Background: NTMT1, a transfer methylase that adds methyl groups to the N-terminus of proteins, has been identified as a…
Bioinformatics analysis of the prognostic and clinical value of senescence-related gene signature in papillary thyroid cancer
Abstract Cellular senescence can both inhibit and promote the occurrence of tumors, so how to apply cellular senescence therapy is…
Comprehensive analysis of the cuproptosis-related gene DLD across cancers: A potential prognostic and immunotherapeutic target
Abstract DLD is a key gene involved in “cuproptosis,” but its roles in tumor progression and immunity remain unclear. Exploring…
Decreased expression of SCARA5 predicts a poor prognosis in melanoma using bioinformatics analysis
Abstract Background: It has been established that the scavenger receptor class A member 5 (SCARA5) functions as a tumor suppressor…
Systematic pan-cancer analysis showed that RAD51AP1 was associated with immune microenvironment, tumor stemness, and prognosis
Abstract Although RAD51 associated protein 1 (RAD51AP1) is crucial in genome stability maintenance, it also promotes cancer development with an…
LINC00958 may be a new prognostic biomarker in various cancers: A meta-analysis and bioinformatics analysis
Abstract Background: There have been many studies on long non-coding RNAs (lncRNAs) as tumor markers. LINC00958 is a lncRNA that…
HOXA-AS2 may be a potential prognostic biomarker in human cancers: A meta-analysis and bioinformatics analysis
Abstract Background: Dysregulation of long non-coding (lncRNA) has been reported in various solid tumors. HOXA cluster antisense RNA 2 (HOXA-AS2)…