LINC00893 inhibits the progression of prostate cancer through miR-3173-5p/SOCS3/JAK2/STAT3 pathway
Abstract Background: Prostate cancer (PCa) is one of the most common malignant tumors in the male urinary system. In recent…
biochemical recurrence prostate cancer
Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death
Abstract Cannabinoids exert anti-cancer actions; however, the underlying cytotoxic mechanisms and the cannabinoid receptors (CBRs) involved remain unclear. In this…
Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis
Abstract Background: Detecting prostate cancer at a non-aggressive stage is the main goal of prostate cancer screening. DNA methylation has…
Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
Abstract Gastric cancer (GC) was one of the most common types of the digestive system. COL8A1 was reported to be…
Co-expression of peripheral olfactory receptors with SARS-CoV-2 infection mediators: Potential implications beyond loss of smell as a COVID-19 symptom
Abstract Severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) enters into human host cells via mechanisms facilitated mostly by angiotensin-converting enzyme…
FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer
Abstract Family with sequence similarity 46 member C (FAM46C) is a non-canonical poly(A) polymerase that is associated with tumorigenesis. However,…
Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression
Abstract Endo-, phyto- and synthetic cannabinoids have been proposed as promising anti-cancer agents able to impair cancer cells’ behavior without…
Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer
Abstract Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic…
Proapoptotic effect of endocannabinoids in prostate cancer cells
Abstract In the early stages, prostate cancer is androgen- dependent; therefore, medical castration has shown significant results during the initial…