Absorption and Bioavailability of Novel UltraShear Nanoemulsion of Cannabidiol in Rats
Abstract Introduction: Cannabidiol (CBD) has several potential benefits and therapeutic uses, especially in pain, inflammation, and anxiety. CBD has high…
bioavailability
Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs
Abstract Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic…
THC-Reduced Cannabis sativa L.—How Does the Solvent Determine the Bioavailability of Cannabinoids Given Orally?
Abstract The bioavailability levels of cannabidiol (CBD) and tetrahydrocannabinol (THC) determine their pharmacological effects. Therefore, for medical purposes, it is…
Antioxidant Effect Assessment and Trans Epithelial Analysis of New Hempseed Protein Hydrolysates
Abstract Hempseed (Cannabis sativa) is one of the most promising sources of plant proteins. It contains approximately 24% (w/w) protein,…
Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
Abstract Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications…
Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment
Abstract Cannabis sativa plants contain a multitude of bioactive substances, which show broad variability between different plant strains. Of the…
Promising Nanocarriers to Enhance Solubility and Bioavailability of Cannabidiol for a Plethora of Therapeutic Opportunities
Abstract In recent years, the interest in cannabidiol (CBD) has increased because of the lack of psychoactive properties. However, CBD…
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
Abstract The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so…
Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb® Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS)
Abstract β-Caryophyllene (BCP), a common constituent of many spice and food plants, is gaining increased attention due to recent research…
The Transdermal Delivery of Therapeutic Cannabinoids
Abstract Recently, several studies have indicated an increased interest in the scientific community regarding the application of Cannabis sativa plants,…