The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba
Abstract Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity of natural products to the benefit of host…
bile acid biosynthesis
The anticancer activity of bile acids in drug discovery and development
Abstract Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder,…
Fasting and refeeding triggers specific changes in bile acid profiles and gut microbiota
Abstract Background: Bile acids (BAs) are closely related to nutrient supply and modified by gut microbiota. Gut microbiota perturbations shape…
Merging enzymatic and synthetic chemistry with computational synthesis planning
Abstract Synthesis planning programs trained on chemical reaction data can design efficient routes to new molecules of interest, but are…
Secondary Terpenes in Cannabis sativa L.: Synthesis and Synergy
Abstract Cannabis is a complex biosynthetic plant, with a long history of medicinal use. While cannabinoids have received the majority…
Biosynthesis of cannabinoid precursor olivetolic acid in genetically engineered Yarrowia lipolytica
Abstract Engineering microbes to produce plant-derived natural products provides an alternate solution to obtain bioactive products. Here we report a…
Postharvest Operations of Cannabis and Their Effect on Cannabinoid Content: A Review
Abstract In recent years, cannabis (Cannabis sativa L.) has been legalized by many countries for production, processing, and use considering…
Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family
Abstract Flavin-dependent enzymes catalyze many oxidations, including formation of ring structures in natural products. The gene cluster for biosynthesis of…
Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years
Abstract Cannabis extracts have been used for centuries, but its main active principle ∆9-tetrahydrocannabinol (THC) was identified about 50 years…