Cannabinoids in Motor Control: From Receptor Distribution to Motor Disorders
Abstract Cannabinoid receptors occupy strategic control nodes within motor circuitry, making them potential targets for modulating different motor manifestations. They…
Basal ganglia
Chronic exposure to inhaled vaporized cannabis high in Δ9-THC suppresses Adderall-induced brain activity
Abstract Background: There are increasing reports of the misuse of prescription psychostimulants for cognitive enhancement together with recreational cannabis. This…
Chronic delta-9-tetrahydrocannabinol (THC) treatment counteracts SIV-induced modulation of proinflammatory microRNA cargo in basal ganglia-derived extracellular vesicles
Abstract Background: Early invasion of the central nervous system (CNS) by human immunodeficiency virus (HIV) (Gray et al. in Brain…
Roles of the Cannabinoid System in the Basal Ganglia in Parkinson’s Disease
Abstract Parkinson’s disease (PD) is a neurodegenerative disease usually caused by neuroinflammation, oxidative stress and other etiologies. Recent studies have…
Fibroblast Growth Factor Signalling in the Diseased Nervous System
Abstract Fibroblast growth factors (FGFs) act as key signalling molecules in brain development, maintenance, and repair. They influence the intricate…
Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington’s Disease
Abstract Several cannabinoids afforded neuroprotection in experimental models of Huntington’s disease (HD). We investigated whether a 1:1 combination of botanical…
Cannabinoids in Parkinson’s Disease
Abstract The endocannabinoid system plays a regulatory role in a number of physiological processes and has been found altered in…
Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection
Abstract Parkinson’s disease (PD) is a slow insidious neurological disorder characterized by a loss of dopaminergic neurons in the midbrain.…
In vivo 1H magnetic resonance spectroscopy in young-adult daily marijuana users☆
Abstract To date, there has been little work describing the neurochemical profile of young, heavy marijuana users. In this study,…
Endocannabinoid Modulation of Dopaminergic Motor Circuits
Abstract There is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in…