Abstract Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily…
Abstract TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and…
Abstract The recent progress in the prediction of protein structures marked a historical milestone. AlphaFold predicted 200 million protein models…
Abstract The high magnitude zoonotic event has caused by Severe Acute Respitarory Syndrome CoronaVirus-2 (SARS-CoV-2) is Coronavirus Disease-2019 (COVID-19) epidemics.…
Abstract The exquisite specificity between a sensor kinase and its cognate response regulator ensures faithful partner selectivity within two-component pairs…
Abstract Ligand-activated signaling through the type 1 insulin-like growth factor receptor (IGF1R) is implicated in many physiological processes ranging from…
Abstract Cyclic di-GMP (c-di-GMP) is a second messenger that modulates multiple responses to environmental and cellular signals in bacteria. Here…
Abstract Coordination of outer membrane constriction with septation is critical to faithful division in Gram-negative bacteria and vital to the…