Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Abstract Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors…
Autophagy
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Abstract Introduction: The accumulation of insoluble proteins within neurons and glia cells is a pathological hallmark of several neurodegenerative diseases.…
Docosahexaenoic acid‐supplementation prior to fasting prevents muscle atrophy in mice
Abstract Background: Muscle wasting prevails in numerous diseases (e.g. diabetes, cardiovascular and kidney diseases, COPD,…) and increases healthcare costs. A…
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
Abstract Gemcitabine (GEM, 2′,2′-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose…