The Endocannabinoid System Contributes to Electroacupuncture Analgesia
Abstract The extensive involvement of the endocannabinoid system (ECS) in vital physiological and cognitive processes of the human body has…
atypical cannabinoid receptors
The endocannabinoid system – current implications for drug development
Abstract In this review, the state of the art for compounds affecting the endocannabinoid (eCB) system is described with a…
Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…
The Interplay between Cancer Biology and the Endocannabinoid System—Significance for Cancer Risk, Prognosis and Response to Treatment
Abstract Simple Summary: This review analyses the complex involvement of the various components of the endocannabinoid system (ECS) in the…
Δ9‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo
Abstract Δ9‐Tetrahydrocannabinol (THC), the main bioactive compound found in the plant Cannabis sativa, exerts its effects by activating cannabinoid receptors…
Bioactive Chemical Composition of Cannabis Extracts and Cannabinoid Receptors
Abstract Cannabis is widely used as a therapeutic drug, especially by patients suffering from psychiatric and neurodegenerative diseases. However, the…
The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations
Abstract Most G protein-coupled receptors that bind the hydrophobic ligands (lipid receptors and steroid receptors) belong to the most populated…
Differential activation of G protein‐mediated signaling by synthetic cannabinoid receptor agonists
Abstract Synthetic cannabinoid receptor agonists (SCRAs) are new psychoactive substances associated with acute intoxication and even death. However, the molecular…
Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism
Abstract We investigated the influence of cannabidiol (CBD) on blood pressure (BP) and heart rate (HR) in spontaneously (SHR) and…
Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity
Abstract Contact hypersensitivity (CHS) is an established animal model for allergic contact dermatitis. Dendritic cells (DCs) play an important role…