The Vertical and Horizontal Pathways in the Monkey Retina Are Modulated by Typical and Atypical Cannabinoid Receptors
Abstract The endocannabinoid (eCB) system has been found in all visual parts of the central ner-vous system and plays a…
atypical cannabinoid receptors
Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
Abstract The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which…
Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s13311-021-01127-1. Article type: Research Article Keywords: Chemotherapy, Neuropathy, Endocannabinoid…
Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?
Abstract Obesity is a complex disorder, and the number of people affected is growing every day. In recent years, research…
The Endocannabinoid System and Cannabidiol: Past, Present, and Prospective for Cardiovascular Diseases
Abstract In the past, cannabis was commonly associated with mysticism and illegality. Fortunately, in recent years perspectives and discourses have…
Alterations in Brain Cannabinoid Receptor Levels Are Associated with HIV-Associated Neurocognitive Disorders in the ART Era: Implications for Therapeutic Strategies Targeting the Endocannabinoid System
Abstract HIV-associated neurocognitive disorders (HAND) persist despite the advent of antiretroviral therapy (ART), suggesting underlying systemic and central nervous system…
Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-021-01196-5. Article type: Research Article Keywords: TAU, Cannabinoid receptor,…
Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling
Abstract The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis…
The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area
Abstract The therapeutic utility of opioids is diminished by their ability to induce rewarding behaviors that may lead to opioid…
Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System—Implications for Health and Disease
Abstract The endocannabinoid system (ECS) employs a huge network of molecules (receptors, ligands, and enzymatic machinery molecules) whose interactions with…