A Humanized CB1R Yeast Biosensor Enables Facile Screening of Cannabinoid Compounds
Abstract Yeast expression of human G-protein-coupled receptors (GPCRs) can be used as a biosensor platform for the detection of pharmaceuticals.…
atypical cannabinoid receptors
Placental Cannabinoid Receptor Expression in Preterm Birth
Abstract Background: The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a…
The CB1 negative allosteric modulator PSNCBAM-1 reduces ethanol self-administration via a nonspecific hypophagic effect
Abstract Alcohol use disorder (AUD) affects >15 million people in the United States. Current pharmacotherapeutic treatments for AUD are only…
Hemp Seed Oil Inhibits the Adipogenicity of the Differentiation-Induced Human Mesenchymal Stem Cells through Suppressing the Cannabinoid Type 1 (CB1)
Abstract Central and peripheral mechanisms of the endocannabinoid system (ECS) favor energy intake and storage. The ECS, especially cannabidiol (CBD)…
The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis
Abstract Aim: Cannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the…
The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement
Abstract Background: The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth…
Cannabinoid receptor ligands modulate fibrosis and inflammation in idiopathic pulmonary fibrosis: a preliminary study
Abstract Background/aim: No specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF) exists. Therefore, new antiinflammatory therapeutic strategies are needed.…
Cannabidiol at Nanomolar Concentrations Negatively Affects Signaling through the Adenosine A2A Receptor
Abstract Cannabidiol (CBD) is a phytocannabinoid with potential as a therapy for a variety of diseases. CBD may act via…
Cannabinoids and the endocannabinoid system in immunotherapy: helpful or harmful?
Abstract Numerous studies in various cancer models have demonstrated that ingredients of cannabis can influence tumor growth through the endocannabinoid…
The relationship between cannabis and anorexia nervosa: a scoping review
Abstract Background: Relapse rates in Anorexia Nervosa (AN) remain high, warranting exploration of further treatments. Cannabinoid agonists are of interest…