Modulation of cellular redox homeostasis by the endocannabinoid system
Abstract The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signalling systems that participate in the…
atypical cannabinoid receptors
Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2
Abstract Chronic pain is commonly and closely correlated with inflammation. Both cannabinoid signaling and mesenchymal stem cells (MSCs) have been…
Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies
Abstract Introduction: Cannabinoids have shown to reduce joint damage in animal models of arthritis and reduce matrix metalloproteinase expression in…
Hormonal status and age differentially affect tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Δ9-THC) on learning in female rats
Abstract The effects of hormone status and age on the development of tolerance to Δ9-THC were assessed in sham-operated (intact)…
Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function
Abstract Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in…
Microinjection of WIN55,212-2 as A Cannabinoid Agonist into The Basolateral Amygdala Induces Sensitization to Morphine in Rats
Abstract Introduction: Previous studies have shown that the basolateral amygdale (BLA) is rich of CB1 cannabinoid receptors and involved in…
Control of synaptic function by endocannabinoid-mediated retrograde signaling
Abstract Since the first reports in 2001, great advances have been made towards the understanding of endocannabinoid-mediated synaptic modulation. Electrophysiological…
Effect of melilotus extract on lung injury by upregulating the expression of cannabinoid CB2 receptors in septic rats
Abstract Background: M. Suaveolens Ledeb has long been used in China to treat inflammatory infectious diseases. Melilotus is extracted from…
The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia
Abstract The endocannabinoid system is widespread throughout the central nervous system and its type 1 receptor (CB1) plays a crucial…
The Endocannabinoid System: A Putative Role in Neurodegenerative Diseases
Abstract Background: Following the characterization of the chemical structure of D9-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, researchers have…