Abstract Background: Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. However, the mechanisms that mediate Δ9-tetrahydrocannabinol…
Abstract Traumatic brain injury (TBI) is a recognized global public health problem. However, there are still limitations in the available…
Abstract Graphical Abstract: Article type: Review Article Keywords: Stroke, Inflammation, Cannabinoids, Neuroinflammation, Neuroprotection, Astrocytes, Microglia, Blood–Brain Barrier Authors: Eman A.…
Abstract Background: Astrocytic reactivity in substance use disorders (SUDs) has been extensively studied, yet the molecular effect of delta-9-tetrahydrocannabinol (∆9-THC,…
Abstract Introduction: Alcohol use disorder (AUD) is commonly associated with anxiety disorders and enhanced stress-sensitivity; symptoms that can worsen during…
Abstract Traumatic brain injury is a global health crisis, causing significant death and disability worldwide. Neuroinflammation that follows traumatic brain…
Abstract Alzheimer’s disease (AD) is a leading neurodegenerative condition causing cognitive and memory decline. With small-molecule drugs targeting Aβ proving…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-023-01655-1. Article type: Research Article Keywords: Astrocytes, Stem cells,…
Abstract Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD),…
Abstract Consumption of cannabis is on the rise as public opinion trends toward acceptance and its consequent legalization. Specifically, the…