Abstract The progressive immune-mediated disease known as multiple sclerosis (MS) is characterized by myelin degradation, inflammation, and neurodegeneration. Recent research…
Abstract Background: Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in…
Abstract Given the increasing use of cannabis in the US, there is an urgent need to better understand the drug’s…
Abstract (1) Background: Frontotemporal lobar degeneration (FTLD) is a generic term which refers to multiple pathologies, including FTLD-tau. The most…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-024-01758-3. Article type: Research Article Keywords: Cerebrospinal fluid, Biomarkers,…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00441-024-03867-w. Article type: Research Article Keywords: Blood brain and…
Abstract In this study, the presence of 11-nor-Δ9-carboxy tetrahydrocannabinol (THC-COOH) in postmortem fluid obtained from the chest cavity (FCC) of…
Abstract Background: Alzheimer’s disease dementia (ADD) may manifest with atypical phenotypes, resembling behavioral variant frontotemporal dementia (bvFTD) and corticobasal syndrome…
Abstract Long-term cannabis use during adolescence has deleterious effects in brain that are largely ascribed to the activation of cannabinoid-1…
Abstract Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies,…