Dysregulation of the endocannabinoid system – a key factor in the progression of multiple sclerosis?
Abstract The endocannabinoid system has been implicated in the pathophysiology of multiple sclerosis (MS), yet its role across different disease…
artificial cerebrospinal fluid
Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Multiple Sclerosis: A Systematic Review
Abstract The progressive immune-mediated disease known as multiple sclerosis (MS) is characterized by myelin degradation, inflammation, and neurodegeneration. Recent research…
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice
Abstract Background: Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in…
Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation
Abstract Given the increasing use of cannabis in the US, there is an urgent need to better understand the drug’s…
Entry of cannabidiol into the fetal, postnatal and adult rat brain
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00441-024-03867-w. Article type: Research Article Keywords: Blood brain and…
11-Nor-9-Carboxy Tetrahydrocannabinol Distribution in Fluid from the Chest Cavity in Cannabis-Related Post-Mortem Cases
Abstract In this study, the presence of 11-nor-Δ9-carboxy tetrahydrocannabinol (THC-COOH) in postmortem fluid obtained from the chest cavity (FCC) of…
Adolescent administration of Δ9-THC decreases the expression and function of muscarinic-1 receptors in prelimbic prefrontal cortical neurons of adult male mice
Abstract Long-term cannabis use during adolescence has deleterious effects in brain that are largely ascribed to the activation of cannabinoid-1…
Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures were eliminated by cannabidiol
Abstract We observed that cannabidiol supplements were highly effective in treating an infant boy with drug-resistant early infantile epileptic encephalopathy,…
Immunity in Gilles de la Tourette-Syndrome: Results From a Cerebrospinal Fluid Study
Abstract Background: Several lines of evidence support the hypothesis of an autoimmune origin of Gilles de la Tourette-Syndrome (GTS). Accordingly,…