Abstract Introduction: Although bariatric surgery profoundly ameliorates type 2 diabetes (T2D), the mechanisms whereby specific procedures confer metabolic benefits through…
Abstract Introduction: Bile BA profiling is important for understanding the pathogenetic mechanisms underlying gallbladder and gastrointestinal diseases. Until now, bile…
Abstract The pathogenesis of fatty liver is highly intricate. The role of the gut-liver axis in the development of fatty…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00204-024-03757-8. Article type: Research Article Keywords: Bile canaliculi, Bile…
Abstract Rapid and accurate clinical staging of pediatric patients with inflammatory bowel disease (IBD) is crucial to determine the appropriate…
Abstract Clostridioides difficile is the leading cause of hospital-acquired diarrhea worldwide. While TcdB, the primary virulence determinant of C. difficile,…
Abstract Background: Intrauterine growth restriction (IUGR) can cause lipid disorders in infants and have long-term adverse effects on their growth…
Abstract Background: Bile acids (BAs) are closely related to nutrient supply and modified by gut microbiota. Gut microbiota perturbations shape…
Abstract Bile acid (BA) synthesis from cholesterol by hepatocytes is inhibited by inflammatory cytokines. Whether liver inflammation also affects BA…
Abstract Background: The pathogenesis of methamphetamine usedisorders (MUDs) remains largely unknown; however, bile acids may play arole as potential mediators…