The multifaceted role of phosphodiesterase 4 in tumor: from tumorigenesis to immunotherapy
Abstract Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in…
Anti-tumor Immunity
Diagnostics and immunological function of CENPN in human tumors: from pan-cancer analysis to validation in breast cancer
Abstract Background: Centromere protein N (CENPN), a member of the centromere protein family, contributes to ribonucleic assembly, mitosis progression, and…
HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors
Abstract Introduction: Endometrial Carcinoma (UCEC) is a prevalent malignant tumor within the female reproductive system. HLA-DMB, the beta chain of…
Pan-Cancer Analysis of KANK2: Clinical and Molecular Insights into Tumor Progression and Therapeutic Implications
Abstract Background: KANK2, a gene crucial for cell migration and movement, is implicated in neoplastic and non-neoplastic diseases. This study…
HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation
Abstract Background: Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular…
Investigating POU3F4 in cancer: Expression patterns, prognostic implications, and functional roles in tumor immunity
Abstract Research has demonstrated that POU3F4 is integral to various cancers, in addition to its significance in inner ear development,…
NEK2 is a potential pan-cancer biomarker and immunotherapy target
Abstract Background: NEK2 is a member of the NEKs family and plays an important role in cell mitosis. Increasing evidence…
Multi-omics analysis identifies PTTG1 as a prognostic biomarker associated with immunotherapy and chemotherapy resistance
Abstract Background: Pituitary tumor-transforming gene 1 (PTTG1) is an important gene in tumour development. However, the relevance of PTTG1 in…
Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer
Abstract Expression of major histocompatibility complex I (MHC-I) on tumor cells is extremely important for the antitumor immune response for…
Comprehensive analysis of PHF5A as a potential prognostic biomarker and therapeutic target across cancers and in hepatocellular carcinoma
Abstract Objective: Cancer is a predominant cause of death globally. PHD-finger domain protein 5 A (PHF5A) has been reported to…