Abstract INTRODUCTION: Primary tauopathies, including corticobasal degeneration (CBD), Pick’s disease (PiD), and progressive supranuclear palsy (PSP), have aggregated tau pathology…
Abstract Tau, a microtubule-binding protein linked to tauopathies like Alzheimer’s disease and frontotemporal lobar degeneration (FTLD), has 3-repeat (3R) and…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-024-02843-6. Article type: Research Article Keywords: Essential tremor, Tau,…
Keywords: Alzheimer’s disease, amyloid, biomarkers, clinical trials, Common Alzheimer’s Disease Research Ontology (CADRO), drug development, inflammation, pharmaceutical companies, repurposed drugs,…
Abstract Alzheimer’s disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of…
Abstract Neurodegenerative tauopathies are caused by the transition of tau protein from a monomer to a toxic aggregate. They include…
Abstract Tau proteins within the adult central nervous system (CNS) are found to be abnormally aggregated into heterogeneous filaments in…
Abstract The mechanism of neuronal dysfunction via tau aggregation in tauopathy patients is controversial. In Alzheimer’s disease (AD), we previously…
Abstract Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by…
Abstract Objective: Parkinson’s disease (PD) has significant clinical overlaps with atypical parkinsonism syndromes (APS), which have a poorer treatment response…