CB2 Cannabinoid Receptor As Potential Target against Alzheimer’s Disease
Abstract The CB2 receptor is one of the components of the endogenous cannabinoid system, a complex network of signaling molecules…
anti-neuroinflammation
Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta
Abstract Background: Alzheimer’s disease is associated with amyloid-beta (Aβ)-induced microglia activation. This pro-inflammatory response promotes neuronal damage, and therapies are…
HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads
Abstract As a popular psychostimulant, methamphetamine (METH) use leads to long-lasting, strong euphoric effects. While METH abuse is common in…
Role of Microglial M1/M2 Polarization in Relapse and Remission of Psychiatric Disorders and Diseases
Abstract Psychiatric disorders such as schizophrenia and major depressive disorder were thought to be caused by neurotransmitter abnormalities. Patients with…
Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
Abstract The limited effectiveness of current therapies against Alzheimer’s disease (AD) highlights the need for intensifying research efforts devoted to…
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models
Abstract In patients with multiple sclerosis (MS), pain is a frequent and disabling symptom. The prevalence is in the range…