CB2 Receptor in Microglia: The Guardian of Self-Control
Abstract Microglia are key to maintaining the homeostasis of the brain. These immune cells of the brain can be our…
anti-neuroinflammation
Can We Treat Neuroinflammation in Alzheimer’s Disease?
Abstract Alzheimer’s disease (AD), considered the most common type of dementia, is characterized by a progressive loss of memory, visuospatial,…
Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic Opportunity
Abstract Simple Summary: Alzheimer’s disease (AD) remains a major challenge for the healthcare system worldwide and, to date, no curative…
Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions
Abstract Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is crucial for developing new therapies for TBI.…
Endocannabinoid Receptors in the CNS: Potential Drug Targets for the Prevention and Treatment of Neurologic and Psychiatric Disorders
Abstract The endocannabinoid system participates in the regulation of CNS homeostasis and functions, including neurotransmission, cell signaling, inflammation and oxidative…
Abnormal Cannabidiol Affects Production of Pro-Inflammatory Mediators and Astrocyte Wound Closure in Primary Astrocytic-Microglial Cocultures
Abstract Abnormal cannabidiol (abn-CBD) exerts neuroprotective effects in vivo and in vitro. In the present study, we investigated the impact…
Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease
Abstract Parkinson’s disease is a neurodegenerative disorder, the motor symptoms of which are associated classically with Lewy body formation and…
Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity
Abstract Different studies have demonstrated that inflammation and alterations in glutamate neurotransmission are two events contributing to the pathophysiology of…
The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids
Abstract Epilepsy is a neurological disorder that affects approximately 50 million people worldwide. There is currently no definitive epilepsy cure.…
The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases
Abstract Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the…