The unfolded protein response links tumor aneuploidy to local immune dysregulation
Abstract Aneuploidy is a chromosomal abnormality associated with poor prognosis in many cancer types. Here, we tested the hypothesis that…
And macrophages (F4-80+)
Prognostic Value and Immunological Role of MORF4-Related Gene-Binding Protein in Human Cancers
Abstract MORF4-related gene-binding protein (MRGBP) is the subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation…
The molecular feature of macrophages in tumor immune microenvironment of glioma patients
Keywords: CDF, cumulative distribution function, CGGA, Chinese Glioma Genome Atlas, CNA, copy number alternations, CNV, copy number variation, CSF-1, colony-stimulating…
OSCAR facilitates malignancy with enhanced metastasis correlating to inhibitory immune microenvironment in multiple cancer types
Abstract Cross talk between tumors and the immune microenvironment play a critical role in the malignant progression. The osteoclast-associated receptor…
Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer
Abstract Macrophages are among the most abundant cells of the tumor microenvironment in head and neck squamous cancer (HNSC). Although…
Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer
Abstract Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate…
The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets
Abstract In physiological conditions, different types of macrophages can be found within the central nervous system (CNS), i.e., microglia, meningeal…
Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia
Abstract Transient receptor potential (TRP) ion channels are widely expressed in several tissues throughout the mammalian organism. Originally, TRP channel…
The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages
Abstract Background: Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder.…
Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy
Abstract A painful neuropathy is frequently observed in people living with human immunodeficiency virus type 1 (HIV-1). The HIV coat…