Endocannabinoids as Guardians of Metastasis
Abstract Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral…
anandamide
Oxyradical Stress, Endocannabinoids, and Atherosclerosis
Abstract Atherosclerosis is responsible for most cardiovascular disease (CVD) and is caused by several factors including hypertension, hypercholesterolemia, and chronic…
Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
Abstract Background: The endocannabinoid (eCB) system, an endogenous lipid signaling system, appears to be dysregulated in depression. The role of…
High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity
Abstract Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to…
Endocannabinoids, Related Compounds and Their Metabolic Routes
Abstract Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the…
Control of synaptic function by endocannabinoid-mediated retrograde signaling
Abstract Since the first reports in 2001, great advances have been made towards the understanding of endocannabinoid-mediated synaptic modulation. Electrophysiological…
Does the Neuroprotective Role of Anandamide Display Diurnal Variations?
Abstract The endocannabinoid system is a component of the neuroprotective mechanisms that an organism displays after traumatic brain injury (TBI).…
Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
Abstract Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the…
Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters
Abstract This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and…
Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones
Abstract Background: In early pregnancy, increased plasma levels of the endocannabinoid anandamide (AEA) are associated with miscarriage through mechanisms that…