Capturing the catalytic intermediates of parkin ubiquitination
Abstract Dysfunction of the E3 ligase parkin is causative for early-onset Parkinson’s disease. Parkin accepts ubiquitin from an E2 conjugating…
Amyotrophic lateral sclerosis vs Parkinson plus
Oral Cannabidiol for Seborrheic Dermatitis in Patients With Parkinson Disease: Randomized Clinical Trial
Abstract Background: Seborrheic dermatitis (SD) affects 18.6%-59% of persons with Parkinson disease (PD), and recent studies provide evidence that oral…
Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles
Abstract The PINK1/Parkin pathway plays an important role in maintaining a healthy pool of mitochondria. Activation of this pathway can…
Transcriptomic and Genetic Associations between Alzheimer’s Disease, Parkinson’s Disease, and Cancer
Abstract Simple Summary: Epidemiological studies have identified a link between neurodegenerative disorders and a reduced risk of overall cancer. Increases…
Biological bases for a possible effect of cannabidiol in Parkinson’s disease
Abstract Current pharmacotherapy of Parkinson’s disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can…
Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes
Abstract Background: 18F-FDG brain PET measures metabolic changes in neurodegenerative disorders and may discriminate between different diseases even at an…