Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice
Abstract Studies on the effective and safe therapeutic dosage of delta-9-tetrahydrocannabinol (THC) for the treatment of Alzheimer’s disease (AD) have…
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Potential and Limits of Cannabinoids in Alzheimer’s Disease Therapy
Abstract Simple Summary: This review was aimed at exploring the potentiality of drugging the endocannabinoid system as a therapeutic option…
TBK1 interacts with tau and enhances neurodegeneration in tauopathy
Abstract One of the defining pathological features of Alzheimer’s disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of…
Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic Opportunity
Abstract Simple Summary: Alzheimer’s disease (AD) remains a major challenge for the healthcare system worldwide and, to date, no curative…
Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells
Abstract In this proof-of-concept study, the antioxidant activity of phytocannabinoids, namely cannabidiol (CBD) and Δ9- tetrahydrocannabinol (THC), were investigated using…