Plasma biomarkers in neuropsychiatric syndromes: A narrative review
Abstract Neuropsychiatric symptoms (NPS) are common features of neurodegenerative disease (NDD) but are relatively understudied compared to cognition, especially regarding…
Alzheimer disease
Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights
Abstract Previous studies have suggested a relationship between the number of CAG triplet repeats in the HTT gene and neurodegenerative…
The Healthy and Diseased Retina Seen through Neuron–Glia Interactions
Abstract The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and…
Behavioral or neuropsychiatric symptoms of Alzheimer’s disease: from psychopathology to pharmacological management
Abstract Neuropsychiatric or behavioral symptoms of dementia encompass a series of disorders, such as anxiety, depression, apathy, psychosis, and agitation,…
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Abstract Alzheimer’s disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of…
Insight into the Binding of First- and Second-Generation PET Tracers to 4R and 3R/4R Tau Protofibrils
Abstract Primary supranuclear palsy (PSP) is a rare neurodegenerative disease that perturbs body movement, eye movement, and walking balance. Similar…
Dissecting the Binding Profile of PET Tracers to Corticobasal Degeneration Tau Fibrils
Abstract Alzheimer’s disease and primary tauopathies are characterized by the presence of tau pathology in brain. Several tau positron emission…
Cannabis Therapeutics and the Future of Neurology
Abstract Neurological therapeutics have been hampered by its inability to advance beyond symptomatic treatment of neurodegenerative disorders into the realm…
Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model
Abstract Background: A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with…
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Abstract Introduction: The accumulation of insoluble proteins within neurons and glia cells is a pathological hallmark of several neurodegenerative diseases.…