Astrocytic GPR55 receptors promote glycolysis
Abstract Background: The endocannabinoid system is closely associated with systemic and cellular energy metabolism in mammals. We previously demonstrated that…
altered mitochondria
The Therapeutic Crossroad Between Mitochondria and Cannabidiol: A Mini-Review
Abstract Cannabidiol is a compound from the plant Cannabis sativa that does not produce psychoactive effects and has increasingly been…
Effects of Cannabidiol on TAFAZZIN‐Deficient B‐Lymphoblastoid Cells
Abstract Barth Syndrome (BTHS) is a debilitating X‐linked genetic disorder caused by mutations in the gene encoding TAFAZZIN, an enzyme…
THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells
Abstract In the search for new therapeutic strategies for the treatment of skin cancer, cannabinoids have become the focus of…
Affinity‐Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor‐Independent Neuroprotection
Abstract Phytocannabinoids are attracting growing attention because of their potential for treatment of neurodegenerative diseases. Among them, the “minor” cannabinoid,…
Cannabidiol Enhances Mitochondrial Metabolism and Antioxidant Defenses in Human Intestinal Epithelial Caco-2 Cells
Abstract Background: The reintroduction of hemp production has resulted in increased consumption of cannabidiol (CBD) products, particularly CBD oil, yet…
Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines
Abstract In our previous study, we demonstrated the impact of overexpression of CB1 and CB2 cannabinoid receptors and the inhibitory…
Cannabidiol Disrupts Mitochondrial Respiration and Metabolism and Dysregulates Trophoblast Cell Differentiation
Abstract Trophoblast differentiation is a crucial process in the formation of the placenta where cytotrophoblasts (CTs) differentiate and fuse to…
Knockdown siRNA targeting GPR55 reveals significant differences between the anti-inflammatory actions of KLS-13019 and cannabidiol
Abstract KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Recent…
Cumulative Deleterious Effects of Tetrahydrocannabinoid (THC) and Ethanol on Mitochondrial Respiration and Reactive Oxygen Species Production Are Enhanced in Old Isolated Cardiac Mitochondria
Abstract Delta 9 tetrahydrocannabinol (THC), the main component of cannabis, has adverse effects on the cardiovascular system, but whether concomitant…